Anesthetic Agent Choice for the MH-Susceptible Patient
The following anesthetic agents are known triggers of MH and are not safe for use in MH-susceptible patients:
Unsafe Anesthetic Agents for MHS Patients
What Drugs trigger MH and are Not Safe? Choroform (Trichloromethane, Methyltrichloride) Desflurane Enflurane Halothane Isoflurane Methoxyflurane Sevoflurane Trichloroethylene Xenon (Rarely Used) Succinylcholine (Suxamethonium)
Inhaled General Anesthetics
Depolarizing Muscle Relaxants Trigger MH
All other anesthetic agents outside of these two categories of Volatile anesthetic agents and depolarizing muscle relaxants are considered safe (see below for a sample).
Safe Anesthetic Agents for MH Patients
Barbiturates / Intravenous Anesthetics
Diazepam Etomidate (Amidate) Hexobarbital Ketamine (Ketalar) Methohexital (Brevital) Midazolam Narcobarbital Propofol (Diprivan) Thiopental (Pentothal) Inhaled Non-Volatile General Anesthetic
Nitrous Oxide Local Anesthetics
Amethocaine Articaine Bupivicaine Dibucaine Etidocaine Eucaine Lidocaine (Xylocaine) Levobupivacaine Prilocaine (Citanest) Ropivacaine Stovaine |
Narcotics (Opioids) Alfentanil (Alfenta) Anileridine Codeine (Methyl Morphine) Diamorphine Fentanyl (Sublimaze) Hydromorphone (Dilaudid) Meperidine (Demerol) Methadone Morphine Naloxone Oxycodone Phenoperidine Remifentanil Sufentanil (Sufenta Safe Muscle Relaxants
Arduan (Pipecuronium) Curare (The active ingredient is Tubocurraine) Gallamine Metocurine Mivacron (Mivacurium) Neuromax (Doxacurium) Nimbex (Cisatracurium) Norcuron (Vecuronium) Pavulon (Pancuronium) Tracrium (Atracurium) Zemuron (Rocuronium) |
Anxiety Relieving Medications
Ativan (Lorazepam) Centrax Dalmane (Flurazepam) Halcion (Triazolam) Klonopin Librax Librium (Chlordiazepoxide) Midazolam (Versed) Paxipam (Halazepam) Restoril (Temazepam) Serax (Oxazepam) Tranxene (Clorazepate) Valium (Diazepam) |
